It is used alone or in combination with other medications to slow or stop cancer cell growth. Cisplatin is a chemotherapy medication used to treat a number of cancers. For directions for the administration of cyclophosphamide, refer to the cyclophosphamide package insert. Cisplatin comes as a liquid that is injected into a vein over six to eight hours in a hospital or medical facility. The active ingredient, cisplatin, is a yellow to orange crystalline powder with the. Cisplatin dosing, indications, interactions, adverse. Due to the unprecedented nature of the covid19 pandemic, anyone reporting an adverse event andor a product complaint via phone, should you receive a network busy signal ie. A novel camptothecin analogue fl118 reduces cisplatin resistance. Alimtais a folate analog metabolic inhibitor indicated. Without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated with cisplatin for injection and may be so severe that.
Should be administered only by or under the direct supervision of a qualified physician who is experienced in the use of cancer chemotherapeutic agents. Cisplatin can cause fetal harm when administered to a pregnant woman. See full prescribing information for complete boxed warning. May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6. Package insert of accord healthcares cisplatin injection, 1 mgml, 50 ml and 100 ml. Only select registry of toxic effects of chemical substances rtecs data is presented here. Nevertheless, due to the nonspecificity and high dosage of drugs in. See actual entry in rtecs for complete information.
Doxorubicincisplatinloaded superparamagnetic nanoparticles as a stimuli responsive codelivery system for chemophotothermal therapy. Cisplatinbased doublets are recommended for adjuvant and neoadjuvant treatment of potentially operable nonsmallcell lung cancer nsclc and firstline therapy for advanced or metastatic nsclc. Premedicate with antiemetic agents see dosage and administration 2. Cisplatin is a commonly used chemotherapy drug and intravenous administration is the most commonly. Cisplatin cisplatin injection drug overview and uses for. The latest nmr studies on the wellknown anticancer drug cisplatin, with focus on. Experiment research of cisplatin implants inhibiting transplantation. A transitionmetal complex that is used in the treatment of cancer, with particular effectiveness in the treatment of testicular and ovarian cancers explanation of cisplatin. Patients received 20 mgm 2day of cisplatin for 5 days and 80 mgm2day of etoposide or etoposide phosphate. Oct 18, 2019 if cisplatin is used in combination chemotherapy, the dose of cisplatin must be reduced. Tumor tissue was collected and homogenized after adding pbs. Current status and new developments is a collection of papers presented at a symposium sponsored by the university of alabama in birmingham comprehensive cancer center and the bristol laboratories in syracuse.
The parent compound, cisplatin, is excreted in the urine and accounts for % to 17% of the dose excreted within one hour after administration of 50 mgm2. Anderson cancer center, 1515 holcombe boulevard, houston, tx 770304009, usa cisplatin is one of the most potent antitumor agents. The use of cisplatin in patients with preexisting kidney dysfunction and the renal effects of the platinum analogs, carboplatin and oxaliplatin, are discussed elsewhere. Recommended dose modifications in patients with cervical cancer. The contents of klk7 and ecad in tumor tissue and serum of tumorbearing mice in four groups were different group a. Lung pathway group pemetrexed and cisplatin in nonsmall. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma.
Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation. A total of 121 patients were randomized and 120 treated 60 per group. The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and. Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp. Cisplatin is an anticancer agent with some side effects. Cad was the least stable compound, with 50% degradation after the. Original article the chemosensitization effect of quercetin on cisplatin induces the apoptosis of human colon cancer ht29 cell line wei jin 1, haiming han, lan ma2, hongmei zhou, cunxin zhao1 1department of gastroenterology, yidu central hospital of weifang, weifang 262500, p. Cisplatin for injection is a platinumbased drug indicated for the treatment of. Jul 09, 20 cisplatin based doublets are recommended for adjuvant and neoadjuvant treatment of potentially operable nonsmallcell lung cancer nsclc and firstline therapy for advanced or metastatic nsclc.
Jul 18, 2017 for directions for the administration of cyclophosphamide, refer to the cyclophosphamide package insert. Save money on your platinolaq injection prescription by switching to tevas fdaapproved generic version, cisplatin injection. Cisplatin is mutagenic in bacteria and produces chromosome aberrations in animal cells in tissue culture. Exercise caution to prevent inadvertent cisplatin overdose as doses greater than 100 mgm2cycle once every 3 to 4 weeks are rarely used. See manufacturers prescribing information for cisplatin administration and hydration guidelines and for cisplatin dosage adjustment in the event of hematologic toxicity. Cisplatin gains entry into tubular cells via uptake by the oct2 system on the basolateral membrane of proximal tubular cells. Cancer drug cisplatin was accidentally discovered to help treat cancer in 1965. Cisplatin is also being studied in the treatment of other types of cancer. See chemotherapy nephrotoxicity and dose modification in patients with kidney impairment. Appropriate management of therapy and complications is. The traditional mechanism is that cisplatin enters the cell, interacts with the dna guanine bases and forms the inter or intrastrand chain crosslinking, then prevents the replication of dna. Apexbio cisplatininhibits dna synthesis,chemotherapy. The recommended dose of alimta when administered with cisplatin in patients with a creatinine clearance calculated by cockcroftgault equation of 45mlmin or greateris 500mgm2 as an intravenous infusion over 10minutes on day 1 of each 21day cycle until disease progression or unacceptable toxicity.
The discovery and development of cisplatin article pdf available in journal of chemical education 835 may 2006 with 4,236 reads how we measure reads. Your dosage will be based on your medical condition, weight, and response to the. An average urine output of at least 100mlhr must be maintained throughout treatment, and cisplatin infusion should not be commenced unless this. For 48 hours after this drug is given, the patients body fluids can contain the drug. Appropriate management of therapy and complications is possible only when adequate. And its been doing exactly that since it was approved for use in 1978. The name of your medicine is cisplatin 1 mgml concentrate for solution for infusion but in the rest of the leaflet it will be called cisplatin injection. Cisplatin may give allergic reactions in some patients. Cisplatin also called platinol is an anticancer medicine. Cisplatin, the active ingredient in cisplatin injection, is a yellow to orange crystalline powder with the molecular formula cl 2 h 6 n 2 pt and a molecular weight of 300. Each vial contains equal parts by weight of carboplatin and mannitol. It is given by injection into a vein common side effects include bone marrow suppression, hearing problems, kidney problems.
Mar 01, 2019 cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. Cisplatin for injection is a highly emetogenic antineoplastic agent. In general, for severe grade 3 or 4 nonhematological toxicity, except alopecia and nauseavomiting, therapy with gemcitabine for injection plus cisplatin should be held or decreased by 50% depending on the judgment of the treating physician. Weight should be recorded prior to and at the end of cisplatin treatment, and a strict fluid balance chart should be maintained. Apexbio cisplatininhibits dna synthesis,chemotherapy drug. Cisplatin side effects are often predictable in terms of their onset, duration, and severity. Full text doxorubicincisplatinloaded superparamagnetic. Mar 10, 2015 cancer drug cisplatin was accidentally discovered to help treat cancer in 1965. Package insert of accord healthcares cisplatin injection. Highlights of prescribing information reduce the dose of. Medlineplus information on cisplatin a lay language summary of important information about this drug that may include the following. Pfizer rxpathways connects eligible patients to a range of assistance programs to help them access their pfizer prescriptions.
A randomized trial of cisplatin, etoposide and bleomycin peb versus carboplatin, etoposide and bleomycin ceb for patients with goodrisk metastatic nonseminomatous germ cell. Cisplatin is fda approved alone or in combination with other drugs to treat people who have certain types of cancer. Cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. At the recommended dosage, platinol should not be given more frequently than once every 3 to 4 weeks see adverse reactions. In combination therapy, cisplatin cisplatin injection and cyclophosphamide are administered sequentially. To view the cisplatin molecule in 3din 3d with jsmol. Adverse reaction or laboratory values recommended dose modification. Fl118, anticancer activity, cisplatin resistance, nsclc, survivin, emt. Happy 50th anniversary to cisplatin, the drug that changed. Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin.
Highlights of prescribing information these highlights do not include all the information needed to use. Cisplatin 1 mgml sterile concentrate summary of product. The ptiv derivative of cisplatin with one axial aspirin and one. Cisplatin may cause severe kidney problems or very serious allergic reactions. Paraplatin carboplatin for injection, usp is supplied as a sterile, lyophilized white powder available in singledose vials containing 50 mg, 150 mg, and 450 mg of carboplatin for administration by intravenous infusion. Cisplatin side effects, dosage, interactions drugs. It is believed to induce apoptosis through several mechanisms. If cisplatin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Cisplatin 1 mgml sterile concentrate should be diluted in 2 litres of 0. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two.
Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Cisplatin side effects will improve after therapy is complete. A typical dose is 20 mgm 2 or more once every 3 to 4 weeks unless in the combination therapy of smallcell and nonsmallcell lung carcinoma, in which a typical dose of 80 mgm 2 is administered. Sigmaaldrich offers a number of cisplatin products. As the firstline drug therapy for nonsmall cell lung cancer nsclc, cisplatin has a wide range of ap plications. Cisplatin fda prescribing information, side effects and uses. Cisplatin 1 mgml concentrate for solution for infusion. In this study, we aimed to demonstrate the effects of the addition of cisplatin which is a widely used antineoplastic drug for osteosarcoma, on the mechanical properties of bone cement, and to evaluate the cytotoxic effects of eluted cisplatin on saos2 cell culture. Cisplatin, cisplatinum or cisdiamminedichloridoplatinumii cddp is a platinumbased chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e. Cisplatin is a platinumbased agent whose nephrotoxicity is thought related to the chloride in the cis position. Highlights of prescribing information platinumresistant. Cisplatin is in a class of drugs known as platinumcontaining compounds used to treat various types of cancers including metastatic testicular.
All caregivers should take safety precautions while giving this drug. Carboplatin carboplatin this product information is intended only for residents of the united states. Each 50 ml or 100 ml amber vial of infusion concentrate contains. Cellular apoptosisnecrosis develops due to endoplasmic reticuluminduced stress, mitochondrial injury pathways, and a death receptor pathway. This medication is usually given by injection into a vein by a health care professional. Docetaxel and cisplatin regimen for nonsmallcell lung cancer. Avastin, in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is indicated for the treatment of patients with persistent, recurrent, or metastatic cervical cancer. Cisplatin is used to treat various types of cancer. Cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. To minimize cisplatin resistance, combinatorial therapies were. To view the cisplatin molecule in 3d in 3d with jsmol. As a single agent, cisplatin cisplatin injection should be administered at a dose of 100 mgm 2 iv per cycle once every four weeks.
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